Advances in epidemiological features and diagnosis and treatment strategies for sepsis
10.3760/cma.j.cn112309-20241231-00457
- VernacularTitle:脓毒症的流行病学特征与诊治策略进展
- Author:
Lan YANG
1
;
Zhonghao WANG
Author Information
1. 四川大学华西医院实验医学科，四川大学华西医院临床检验医学研究中心，四川省医学检验临床医学研究中心，成都 610041
- Publication Type:Journal Article
- Keywords:
Sepsis;
Immune suppression;
Next-generation sequencing;
Bloodstream infection;
Immune tolerance
- From:
Chinese Journal of Microbiology and Immunology
2025;45(11):979-984
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is a life-threatening organ dysfunction caused by dysregulated host responses to infection and remains a leading cause of mortality in intensive care unit（ICU）. In China，the incidence and mortality rate of sepsis are relatively high，with children and the elderly being more susceptible. The pathogenesis of sepsis is complex，primarily involving gram-negative bacteria and multidrug-resistant strains. Traditional blood culture，regarded as the "gold standard" for diagnosis，has limitations in terms of sensitivity and time consumption，whereas next-generation sequencing technology，characterized by its rapidity and high sensitivity，shows potential value in pathogen detection and treatment optimization. To effectively reduce the disease burden of sepsis in China，future research should focus on elucidating the immunological mechanisms of sepsis and developing precise strategies for classification and personalized treatment. Additionally，enhancing healthcare resource allocation and ICU accessibility are also crucial. This article summarizes the epidemiological characteristics of sepsis and systematically reviews the advances in pathogen diagnostic techniques and stratified treatment for sepsis，aiming to provide a reference for the precision diagnosis and treatment of sepsis.
