Research progress in therapeutic human papillomavirus vaccines
10.3760/cma.j.cn112309-20241031-00372
- VernacularTitle:治疗性人乳头瘤病毒疫苗研究进展
- Author:
Pengju YU
1
;
Weijin HUANG
;
Weilu LIU
;
Jianhui NIE
Author Information
1. 沈阳药科大学药学院，沈阳 110016
- Publication Type:Journal Article
- Keywords:
Human papillomavirus;
Cervical cancer;
Therapeutic vaccines;
Immunogen design;
Clinical research
- From:
Chinese Journal of Microbiology and Immunology
2025;45(11):965-973
- CountryChina
- Language:Chinese
-
Abstract:
Cervical cancer is the fourth most prevalent cancer among women worldwide，which is closely related to human papillomavirus（HPV）infection. Since prophylactic HPV vaccines cannot clear established infections，therapeutic HPV vaccines are urgently needed to induce a cytotoxic T cell-dominated immune response to clear HPV infections or improve HPV-related conditions. This article systematically reviews the immune design strategy，research and development platform，and clinical research progress of therapeutic HPV vaccines，aiming to provide ideas for the research and development of therapeutic HPV vaccines.
