Discovery journey and future prospects of Foxp3? regulatory T cells：an interpretation of the 2025 Nobel Prize in Physiology or Medicine
10.3760/cma.j.cn112309-20251020-00344
- VernacularTitle:Foxp3 +调节性T细胞的发现历程及未来展望
- Author:
Cheng PENG
1
;
Dan LI
;
Huilin CAO
;
Bin LI
Author Information
1. 上海交通大学医学院海南国际医学中心临床免疫与治疗实验室，琼海 571400
- Publication Type:Journal Article
- Keywords:
Regulatory T cell;
Peripheral immune tolerance;
Clinical application;
Nobel Prize
- From:
Chinese Journal of Microbiology and Immunology
2025;45(11):897-905
- CountryChina
- Language:Chinese
-
Abstract:
The immune system maintains a delicate balance between effectively defending against infections and avoiding attacks on self-tissues，a dynamic equilibrium that has long puzzled immunologists. The 2025 Nobel Prize in Physiology or Medicine was awarded to Mary E. Brunkow，Fred Ramsdell，and Shimon Sakaguchi for their identification of regulatory T cells（Treg）and Foxp3，systematic discovery of the critical role of CD4 +CD25 +Foxp3 + Treg cells in suppressing autoimmune responses，thereby establishing the field of Treg cell-mediated peripheral immune tolerance. This groundbreaking work not only reshapes the understanding of immune regulation，but also but also expands the clinical applications of Treg cells into multiple fields，including autoimmune diseases（e.g.，typeⅠ diabetes，multiple sclerosis），cancer immunotherapy（e.g.，targeting tumor-infiltrating Tregs），and transplant tolerance induction. Advances in gene editing and artificial intelligence are further driving personalized precision medicine. Treg cell therapies hold promise for revolutionizing the treatment of immune-related diseases.
