Seroepidemiology of pertussis among healthy people aged 1-14 years old in Shaanxi Province in 2017
10.3760/cma.j.cn112309-20240902-00317
- VernacularTitle:2017年陕西省1~14岁健康人群百日咳血清流行病学调查
- Author:
Chao ZHANG
1
;
Tiantian ZHOU
1
;
Siwen LI
1
;
Weijun HU
1
Author Information
1. 陕西省疾病预防控制中心免疫规划所，西安 710054
- Publication Type:Journal Article
- Keywords:
Pertussis;
Pertussis toxin;
Antibody;
Healthy people
- From:
Chinese Journal of Microbiology and Immunology
2025;45(11):942-948
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To estimate the incidence of Bordetella pertussis（ Bp）infection by analyzing the seroepidemiological characteristics of pertussis in healthy people aged 1-14 years in Shaanxi Province in 2017. Methods:A stratified random sampling method was used to select healthy people aged 1-14 years from 30 county-level disease surveillance sites in 10 cities of Shaanxi Province in 2017. Serum IgG antibodies against pertussis toxin（PT-IgG）were quantitatively detected by ELISA. The incidence of Bp infection within one year（PT-IgG≥100 IU/ml）and the geometric mean concentration（GMC）of PT-IgG were analyzed. Statistical analysis was performed using Mann-Whitney U test，Kruskal-Wallis test，or Jonckheere-Terpstra test. Results:A total of 1 777 subjects were included. The incidence of Bp infection within one year was 0.84%（15/1 777）and the GMC of PT-IgG was 5.70 IU/ml. The incidence of Bp infection within one year in different age groups ranged from 0 to 3.06%（3/98），and the GMC of PT-IgG was between 2.99 IU/ml and 9.29 IU/ml. People aged 12-14 years showed higher incidence of Bp infection within one year. The estimated incidence of Bp infection in people aged 5-14 years was 6 639.97/100 000，with the lowest incidence in people aged 5-6 years（2 016.85/100 000）and the highest in people aged 13-14 years（15 425.95/100 000）. The estimated incidence of Bp infection increased with age（ χ 2trend=12 090， P<0.01）. Conclusions:The actual incidence of Bp infection in healthy people aged 1-14 years in Shaanxi Province is high，and the duration of antibody responses to vaccination is limited. Children and adolescents are high-risk groups for pertussis，and attention should be paid to people aged 12-14 years. It is recommended to strengthen the routine monitoring of pertussis in order to better adjust and optimize the immunization strategy.
