Epidemiological analysis of the adhesion glycoprotein gene characteristics of human respiratory syncytial virus in Xi'an from 2023 to 2024
10.3760/cma.j.cn112309-20250115-00015
- VernacularTitle:2023—2024年西安市人呼吸道合胞病毒流行情况及黏附糖蛋白基因特征分析
- Author:
Peng ZHANG
1
;
Yangni DENG
1
;
Shuling LI
1
;
Yuewen HAN
1
;
Yujie YANG
1
;
Jianing WEI
1
;
Ye ZHANG
1
;
Yuanyuan DUAN
1
;
Rui WU
1
;
Hailong CHEN
1
Author Information
1. 西安市疾病预防控制中心病毒病检验科，西安 710054
- Publication Type:Journal Article
- Keywords:
Respiratory syncytial virus;
Adhesion glycoprotein;
Respiratory tract infection;
Evolutionary characterization
- From:
Chinese Journal of Microbiology and Immunology
2025;45(10):809-816
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the prevalence of human respiratory syncytial virus（RSV）and the evolutionary characteristics of the adhesion glycoprotein（G）gene in Xi'an from 2023 to 2024.Methods:Respiratory specimens were collected from patients with acute respiratory infections in Xi'an between October 2023 to October 2024. RSV nucleic acid screening was performed using real-time fluorescence quantitative PCR；full-length G gene sequencing was conducted on nucleic acid-positive specimens. Genotyping characterization of the obtained sequences was performed using Nextclade v3.10.0 software.Results:A total of 2 548 respiratory tract infection samples were collected，with 104 cases（4.08%，104/2 548）testing positive for RSV. The highest RSV positivity rate was observed in children aged ≤1 year（12.24%，18/147），and significant difference in positivity rates were found among age groups（χ 2=37.868， P<0.001）. Since October 2023，RSV has seen an epidemic peak during January to February 2024，and gradually declined thereafter，with no positive cases from May to September 2024. Among the 43 RSV-positive samples，12 strains were identified as subtype A（all genotype A.D.3），and 31 strains were subtype B（14 genotype B.D.4.1.1 and 17 genotype B.D.E.1）. Conclusion:From October 2023 to October 2024，RSV had an epidemic peak in January and February in Xi＇an，with subtype B being the predominant circulating type.
