Super-enhancers in immune diseases: roles and research progress
10.3760/cma.j.cn112309-20240803-00297
- VernacularTitle:超级增强子在免疫性疾病中的效应及研究进展
- Author:
Xinying WANG
1
;
Jingyi XU
;
Fei WANG
;
Hua LIU
Author Information
1. 浙江大学医学院，杭州 310058
- Publication Type:Journal Article
- Keywords:
Enhancer;
Immune diseases;
Pathogenic mechanism;
Research techniques
- From:
Chinese Journal of Microbiology and Immunology
2025;45(9):802-808
- CountryChina
- Language:Chinese
-
Abstract:
Super-enhancers are highly transcriptionally active epigenetic regulatory regions enriched with multiple enhancers, playing a crucial role in regulating gene activity and cell specialization. These regions are closely associated with tissue characteristics and disease development. While current research on super enhancers predominantly focuses on cancer and development, studies related to immune diseases are still in their infancy. This paper systematically reviews the potential applications of super enhancers in immune diseases, the related research techniques and methods, and the progress in understanding their roles in disease development. The aim is to provide a reference for developing super enhancer-based therapeutic strategies and to offer more effective treatment options for immune diseases.
