Etiological and immunological features of a case of Clostridium ramosum infection-induced septic shock secondary to perianal abscess
10.3760/cma.j.cn112309-20241210-00421
- VernacularTitle:1例肛周脓肿继发多枝梭菌感染致脓毒性休克病例的病原学及免疫学特征分析
- Author:
Qinfang TANG
1
;
Dongmei YAN
1
;
Qingping FU
1
;
Yaru ZHI
1
;
Aiting CAI
1
;
Ziyuan DAI
1
;
Lihua XIAO
1
Author Information
1. 南通大学第六附属医院/盐城市第三人民医院检验科，盐城 224001
- Publication Type:Journal Article
- Keywords:
Perianal abscess;
Clostridium ramosum;
Septic shock;
Bloodstream infection
- From:
Chinese Journal of Microbiology and Immunology
2025;45(7):567-569
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the etiological characteristics of Clostridium ramosum DZS3717106 isolated from the blood of a patient with septic shock secondary to perianal abscess and the immunological characteristics of the patient. Methods:The isolate was subjected to morphological observation, mass spectrometry, antibiotic susceptibility testing, and 16S rRNA sequencing. Biochemical and cytological test results of the patient were collected. Flow cytometry was used to detect T cell subsets. Impacts of the virulence factors of the isolate on the host immune system were evaluated.Results:DZS3717106 was an anaerobic Clostridium with pleomorphic rod-shaped cells and spores. It was sensitive to penicillin G, piperacillin/tazobactam, and metronidazole, but resistant to clindamycin. It carried various virulence and resistance genes. The patient was immunocompromised with abnormal IL-6, IL-8, and IL-10 levels. Conclusions:Septic shock caused by Clostridium ramosum is rare, and more research is needed on the causes and epidemiology. DZS3717106 infection triggers over-activated inflammatory response in the patient, which may be closely related to the occurrence and development of septic shock.
