Correlation and influencing factors of sarcopenia with cardiac structure and function in elderly inpatients
10.3760/cma.j.issn.0254-9026.2024.12.008
- VernacularTitle:老年住院患者肌少症与心脏结构功能的关联性及影响因素分析
- Author:
Yu SONG
1
;
Yiwen XING
1
;
Pan LIU
1
;
Yiming PAN
1
;
Jiatong LI
1
;
Yaxin ZHANG
1
;
Yumeng CHEN
1
;
Jing LI
1
;
Lina MA
1
Author Information
1. 首都医科大学宣武医院老年医学科 国家老年疾病临床医学研究中心，北京 100053
- Publication Type:Journal Article
- Keywords:
Sarcopenia;
Cardiac structure;
Cardiac function;
Elderly
- From:
Chinese Journal of Geriatrics
2024;43(12):1556-1561
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation and influencing factors between sarcopenia and cardiac structure and function in elderly inpatients.Methods:A total of 945 elderly patients, aged 60 years and older, were recruited from the Geriatrics Department at Xuanwu Hospital.Sarcopenia was assessed, while cardiac structure and function were evaluated through echocardiography and NT-proBNP measurements.Results:Patients were classified into two groups: a sarcopenia group(n=185, 19.6%)and a non-sarcopenia group(n=760, 80.4%).Compared to the non-sarcopenia group, the sarcopenia group exhibited a reduction in left atrial diameter(LAD), left ventricular end-diastolic diameter(LVEDD), left ventricular mass(LVM), stroke volume(SV), and cardiac output(CO)(all P<0.05).In contrast, NT-proBNP levels were significantly elevated in the sarcopenia group( P<0.001).Multivariate logistic regression analysis identified older age( OR=1.080, P<0.001)and elevated NT-proBNP( OR=1.001, P<0.001)as independent risk factors for sarcopenia.Conversely, higher LAD( OR=0.858, P<0.001)and LVM( OR=0.988, P=0.002)were recognized as independent protective factors.Additionally, NT-proBNP demonstrated a negative correlation with handgrip strength( r=-0.241, P<0.001), gait speed( r=-0.215, P<0.001), SPPB score( r=-0.270, P<0.001), and appendicular skeletal muscle mass(ASM)( r=-0.208, P<0.001), while exhibiting a positive correlation with the 5-time chair stand test( r=0.169, P<0.001).LVM was positively correlated with handgrip strength( r=0.213, P<0.001)and ASM( r=0.456, P<0.001).Furthermore, LAD was positively correlated with handgrip strength( r=0.071, P=0.029)and ASM( r=0.305, P<0.001). Conclusions:Notably, significant differences exist in cardiac structure and function between elderly patients with sarcopenia and those without.Furthermore, indicators related to sarcopenia are correlated with alterations in cardiac structure and function.
