Progress of the LuxS/AI-2 quorum sensing system and its inhibitors in Porphyromonas gingivalis
10.3760/cma.j.cn112309-20240227-00060
- VernacularTitle:牙龈卟啉单胞菌的LuxS/AI-2型群体感应系统及其抑制剂的研究进展
- Author:
Liuping YU
1
;
Yannan CAO
;
Meichun HU
;
Tiankai ZHANG
;
Zhuang DING
;
Yufeng GAO
;
Yanxiao ZHANG
;
Fangyong ZHU
Author Information
1. 江南大学无锡医学院，无锡 214122
- Publication Type:Journal Article
- Keywords:
Porphyromonas gingivalis;
LuxS/AI-2 quorum sensing system;
Quorum sensing inhibitor
- From:
Chinese Journal of Microbiology and Immunology
2025;45(2):168-174
- CountryChina
- Language:Chinese
-
Abstract:
Porphyromonas gingivalis is an important pathogenic bacterium causing a variety of oral and systemic diseases. The LuxS/AI-2 quorum sensing system plays a key role in regulating numerous physiological processes such as biofilm formation, virulence factors and drug resistance in Porphyromonas gingivalis. Quorum sensing inhibitors are a new potential antibiotic substitute, a new method to control bacterial infection under the inhibition of biofilm formation, bacterial virulence and no induction of antibiotic resistance. This review is a summary of the research progress of the LuxS/AI-2 quorum sensing system in regulating biofilm formation, virulence, resistance and quorum sensing inhibitors in Porphyromonas gingivalis, and provides a theoretical basis for further research on the inhibitory targets of the LuxS/AI-2 quorum sensing system in Porphyromonas gingivalis.
