Progress in the role of autophagy receptors in the regulation of viral infections
10.3760/cma.j.cn112309-20240508-00162
- VernacularTitle:自噬受体对病毒感染调控作用的研究进展
- Author:
Rongqian MO
1
;
Rongrong CHENG
;
Xiangrong LI
;
Ruofei FENG
Author Information
1. 西北民族大学生物医学研究中心，生物工程与技术国家民委重点实验室，兰州 730030
- Publication Type:Journal Article
- Keywords:
Autophagy;
Autophagy receptor;
Viral infection
- From:
Chinese Journal of Microbiology and Immunology
2025;45(2):156-167
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy, a highly conserved and lysosome-dependent intracellular catabolic process, plays an important role in maintaining cellular homeostasis and adapting to various cellular stresses. Autophagy receptor involved in autophagy is more selective and effective in recognising and degrading protein aggregates and dysfunctional or redundant organelles in cells, especially pathogens invading into the cells, in order to maintain the homeostasis of the organism; Some viruses can also antagonise or take hostage autophagy receptor, and make use of autophagy to target the degradation of host proteins, thereby increasing their self-infection. In this paper, we review the structure and function of autophagy receptors, and discuss the role of viruses that use autophagy receptors to proliferate and infect the host, so as to provide references for the development of related viral diseases and the search for specific antiviral therapeutic targets.
