Research status and prospect of universal influenza vaccine
10.3760/cma.j.cn112309-20250103-00003
- VernacularTitle:广谱流感疫苗研究现状与展望
- Author:
Xiaoyu CAI
1
;
Xinyu YUE
;
Yaoqing CHEN
;
Yuelong SHU
Author Information
1. 中山大学公共卫生学院（深圳），深圳 518107
- Publication Type:Journal Article
- Keywords:
Influenza virus;
Universal influenza vaccine;
Hemagglutinin;
Neuraminidase;
Mucosal vaccine
- From:
Chinese Journal of Microbiology and Immunology
2025;45(1):2-9
- CountryChina
- Language:Chinese
-
Abstract:
Influenza has high morbidity worldwide, affecting people of all ages, with the greatest impact on children and the elderly. Vaccination is one of the most cost-effective means to reduce the burden of influenza. However, due to the antigenic drift and shift of influenza viruses, the protection rate of the current seasonal influenza vaccines is not ideal, and the protection they provide against potential influenza pandemics is very limited. Therefore, it is of great significance to develop a universal influenza vaccine that has cross-immune protection against different subtypes of influenza virus. This article discusses several key factors of universal influenza vaccines and the current research progress, and prospects the future development trend of universal influenza vaccines.
