Study on the combination of community acquired respiratory distress syndrome toxin and IFN-γ to predict refractory Mycoplasma pneumoniae pneumonia in children
10.3760/cma.j.cn112309-20231108-00124
- VernacularTitle:社区获得性呼吸窘迫综合征毒素联合IFN-γ在儿童难治性支原体肺炎中检测价值的研究
- Author:
Baoying ZHENG
1
;
Hanyu FU
;
Guanhua XUE
;
Ling CAO
Author Information
1. 首都儿科研究所附属儿童医院呼吸内科，北京 100020
- Publication Type:Journal Article
- Keywords:
Mycoplasma pneumoniae pneumonia;
Community acquired respiratory distress syndrome toxin;
Risk factor;
Children
- From:
Chinese Journal of Microbiology and Immunology
2024;44(12):1011-1017
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the value of community acquired respiratory distress syndrome (CARDS) toxin combined with IFN-γ in the early prediction of refractory Mycoplasma pneumoniae pneumonia (RMPP). Methods:A total of 100 children diagnosed with Mycoplasma pneumoniae pneumonia (MPP) were selected as the study objects. Among them, 36 cases were diagnosed with RMPP and 64 cases without RMPP were set as control group. The general data, clinical symptoms, signs, laboratory tests and internal and external pulmonary complications were compared between the two groups. The independent risk factors for RMPP was analyzed by Binary Logistic regression, and receiver operating characteristic (ROC) curve was used to analyze the predictive value of the indicators. Results:The fever time and hospital stay in RMPP group were significantly longer than those in control group, the relative expression of CARDS toxin, neutrophil ratio, C-reactive protein, D-dimer, lactate dehydrogenase, IL-6 and IFN-γ levels in RMPP group were higher than those in control group, and the differences were statistically significant. Binary Logistic regression analysis showed that long fever duration, increased expression of IFN-γ and CARDS toxin and extrapulmonary complications were independent risk factors for RMPP. ROC curves were drawn for the three continuous variables of fever time, IFN-γ, and relative expression of CARDS toxin, the sensitivity and specificity of the combined prediction of the three indexes were 86.1% and 73.4%, respectively.Conclusions:CARDS toxin is closely related to MPP. Fever duration, IFN-γ, relative expression of CARDS toxin and extrapulmonary complications are independent risk factors for RMPP. Especially when the fever time is more than 10.5 d, IFN-γ is more than 31.79 pg/ml, and the relative expression of CARDS toxin is more than 1.18, the possibility of RMPP should be noted.
