Progress in roles of NLRC3 in immune response and immune-related diseases
10.3760/cma.j.cn112309-20231127-00152
- VernacularTitle:NLRC3在免疫应答及免疫相关疾病方面的研究进展
- Author:
Na MENG
1
;
Wenjuan XU
1
Author Information
1. 青岛大学附属医院呼吸与危重症医学科，青岛 266000
- Publication Type:Journal Article
- Keywords:
NOD-like receptor;
NLRC3;
Immune response;
Immune-related diseases
- From:
Chinese Journal of Microbiology and Immunology
2025;45(2):175-180
- CountryChina
- Language:Chinese
-
Abstract:
NOD-like receptor family with a caspase activation and recruitment domain containing 3 (NLRC3), as a negative regulator in NOD-like receptors, plays a suppressive role in the antigen recognition and presentation phase, lymphocyte proliferation and activation phase, and antigen elimination phase mainly through interacting with p38 signaling molecule, NF-κB-nuclear factor of activated T cells 5 complex (NF-κB-NFAT5) signaling pathway, and mitogen-activated protein kinase/extracellular regulated protein kinase (MEK-ERK) signaling pathway. Moreover, NLRC3 plays a crucial role in many immune-related diseases, such as infectious disease, autoimmune diseases, and tumor. In this review, the various functions and related mechanisms of NLRC3 in different immune response phases and immune-related diseases are summarized.
