Diffuse large B-cell lymphoma with acquired von Willebrand syndrome: a case report and literature review

VernacularTitle:以获得性血管性血友病综合征发病的弥漫大B细胞淋巴瘤1例报告并文献复习
Author: Fengdi WANG ¹ ; Bingjie DING ; Mengjuan LI ; Xuewen SONG ; Junxia HU ; Liu LIU ; Hu ZHOU
Author Information

1. 郑州大学附属肿瘤医院（河南省肿瘤医院），郑州　450008
Publication Type:Journal Article
From: Chinese Journal of Hematology 2025;46(11):1068-1071
CountryChina
Language:Chinese
Abstract: This article reports the diagnosis and treatment of a patient with diffuse large B-cell lymphoma (DLBCL) initially manifested as acquired von Willebrand syndrome (AvWS), along with a literature review. The patient, a 22-year-old male, was diagnosed with hereditary von Willebrand disease at the initial stage due to repeated mucosal bleeding, and was later diagnosed with DLBCL (non germinal center type, Ann Arbor stage Ⅳ) due to chest wall mass. Through chemotherapy combined with autologous hematopoietic stem cell transplantation and zebutinib maintenance therapy, the patient achieved sustained complete remission, and the coagulation function returned to normal. This case provides an important reference for the diagnosis and treatment of lymphoma associated AvWS, and highlights the importance of early recognition of basic diseases.