Chemotherapy-free induction therapy for a critically ill pregnant woman with Philadelphia chromosome-positive acute lymphoblastic leukemia: a case report and literature review
10.3760/cma.j.cn121090-20250519-00235
- VernacularTitle:无化疗诱导救治Ph阳性急性淋巴细胞白血病危重产妇1例报告并文献复习
- Author:
Meng GAO
1
;
Yan XIE
;
Ziyi LIU
;
Peiqi LIANG
;
Limin LIU
;
Jie YIN
;
Dong WANG
;
Bing HAN
;
Huiying QIU
;
Jianhong FU
;
Depei WU
Author Information
1. 苏州大学附属第一医院血液科ICU，国家血液系统疾病临床医学研究中心，苏州 215006
- Publication Type:Journal Article
- From:
Chinese Journal of Hematology
2025;46(10):967-971
- CountryChina
- Language:Chinese
-
Abstract:
This report presents the management of a critically ill 36-year-old woman diagnosed with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph +ALL) at 28 weeks of gestation. The patient rapidly deteriorated, developing disseminated intravascular coagulation (DIC) , diffuse alveolar hemorrhage (DAH) , septic shock, and multi-organ dysfunction, necessitating admission to the hematological intensive care unit. Given her critical condition and advanced pregnancy, a chemotherapy-free induction regimen comprising imatinib and dexamethasone was initiated, alongside comprehensive supportive measures, including mechanical ventilation, continuous renal replacement therapy (CRRT) , broad-spectrum antibiotics, and high-dose corticosteroids. During treatment, intrauterine fetal demise occurred, and a stillborn was delivered following obstetric intervention. With aggressive treatment, the patient's respiratory failure, DIC, and DAH gradually resolved, and she achieved complete remission. She subsequently received consolidation chemotherapy, CAR-T cell therapy, and allogeneic hematopoietic stem cell transplantation, achieving sustained complete molecular remission on long-term follow-up. This case demonstrates that for critically ill pregnant patients with Ph + ALL, a chemotherapy-free regimen of targeted therapy and corticosteroids, when combined with intensive supportive care, is a safe and effective approach that may offer a therapeutic option for similar cases.
