High-frequency repetitive transcranial magnetic stimulation can significantly alleviate the anxiety and depression attending medication overuse headache
10.3760/cma.j.cn421666-20240306-00167
- VernacularTitle:高频重复经颅磁刺激治疗药物过度使用性头痛的疗效观察
- Author:
Huiping ZHANG
1
;
Shanshan HONG
1
;
Yu KONG
1
;
Jiangfang MIAO
1
;
Bojun HAN
1
;
Feng HAN
1
Author Information
1. 南通大学附属江阴医院（江阴市人民医院）神经内科，江阴 214400
- Publication Type:Journal Article
- Keywords:
Medication overuse;
Headache;
Transcranial magnetic stimulation;
Cognition;
Depression;
Anxiety;
Sleep
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2025;47(9):841-846
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe any therapeutic effect of repeated high-frequency transcranial magnetic stimulation (rTMS) on patients with medication overuse headache (MOH).Methods:Fifty-seven persons with MOH were divided at random into a control group of 29 cases and an rTMS group of 28 cases. Both groups of patients stopped taking analgesics and were treated with topiramate and trazodone. The rTMS group received an additional 20 minutes of rTMS treatment daily, 5 days a week for 8 consecutive weeks. The control group received sham stimulation. Before and after the treatment, both groups′ headache symptoms, disability, depression, anxiety, cognition and sleep quality were evaluated using a visual analog scale (VAS) for pain, a migraine disability assessment scale (MIDAS), the Montreal cognitive assessment (MoCA), the Hamilton depression scale (HAMD), the Hamilton anxiety scale (HAMA) and the Pittsburgh sleep quality index (PSQI). Auditory event-related potential P300 was also measured for both groups.Results:After the treatment, the average VAS, MIDAS, HAMD, HAMA and PSQI scores of both groups had decreased significantly. The HAMD, HAMA and PSQI average scores of the rTMS group were then significantly better than the control group′s averages. The average MoCA score of the rTMS group had also improved significantly. The average latency of the auditory event-related potential P300 in the rTMS group was then (368.25±9.25)ms and its amplitude was (6.62±1.40)μV, showing significant improvement compared to before the treatment and compared with the control group.Conclusions:On the basis of oral administration of topiramate and trazodone, additional high-frequency rTMS treatment can significantly alleviate anxiety and depression in MOH patients, and improve their sleep quality and the latency and amplitude of event-related potential P300.
