Continuous theta burst stimulation of multiple targets in the treatment of post-stroke aphasia
10.3760/cma.j.cn421666-20250211-00129
- VernacularTitle:连续Theta爆发式经颅磁刺激治疗脑卒中后失语症的疗效观察
- Author:
Fang ZHANG
1
;
Boduo XIE
;
Huaping GUO
;
Lijie GOU
Author Information
1. 承德医学院附属医院，承德 067000
- Publication Type:Journal Article
- Keywords:
Theta burst stimulation;
Stroke;
Aphasia;
Quality of life;
Speech therapy;
Language therapy
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2025;47(9):804-808
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the clinical efficacy of continuous theta burst stimulation in the treatment of post-stroke aphasia (PSA).Methods:Forty-six patients with post-stroke aphasia were randomly divided into an observation group and a control group, with 23 cases in each group. In addition to conventional rehabilitation and speech-language therapy, the observation group received daily theta burst stimulation (cTBS) targeting the contralesional inferior frontal gyrus, the superior temporal gyrus, and the superior frontal gyrus. The control group received sham stimulation over the same areas. The treatment was 5 days per week for 3 weeks. Before and after the treatment, both groups were evaluated using the China Rehabilitation Research Center′s aphasia examination method (CRRCAE), the Boston diagnostic aphasia examination (BDAE), the brief mental scale (MMSE), and the Stroke Aphasia Quality of Life scale (SAQOL-39).Results:After the treatment, intra-group comparison showed significantly greater improvements among the observation group in terms of their average CRRCAE listening comprehension (112.74±8.935), repetition (115.74±16.015), speaking (99.91±6.273), oral reading (98.22±14.087), and reading (86.57±8.101) sub-scores and their average BDAE [3.00 (3.00, 4.00)], MMSE [21.00 (20.00, 24.00)] and SAQOL-39 (112.96±21.995) scores.Conclusions:Continuous theta burst transcranial magnetic stimulation can effectively improve the speech, cognition and life quality of persons with post-stroke aphasia. This therapy is worthy of clinical application and promotion.
