Low-frequency amplitude changes in the brains of children with global developmental delay in response to natural stimuli: a study usig the functional near-infrared spectroscopy
10.3760/cma.j.cn421666-20250301-00188
- VernacularTitle:基于功能性近红外光谱成像技术观察全面发育迟缓患儿在自然刺激范式下的脑功能低频振幅变化
- Author:
Jiaoyang SHAN
1
;
Weihang QI
;
Yi ZHANG
;
Zhichong HUI
;
Shaoqing LI
;
Yuwei SU
;
Kaili SHI
;
Mingmei WANG
;
Dengna ZHU
Author Information
1. 郑州大学第三附属医院康复医学科，郑州市儿童脑瘫防治重点实验室，郑州 450052
- Publication Type:Journal Article
- Keywords:
Functional near-infrared spectroscopy;
Global developmental delay;
Naturalistic stimuli;
Low-frequency amplitude fluctuations
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2025;47(8):740-744
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the differences in the standardized z-score amplitude of low-frequency fluctuations (zALFFs) across different brain regions between children with global developmental delay (GDD) and healthy children (HC) using functional near-infrared spectroscopy (fNIRS), and correlating zALFF values with the subjects′ Gesell Developmental Scale (GDS) scores.Methods:Thirty-one children aged 2-4 years with GDD and 29 HC of the same age were studied. fNIRS was used to record both groups′ brain activity in response to natural stimuli and to measure any changes in oxygenated hemoglobin (HbO) levels in cerebral blood flow. zALFF values were calculated and the values of 44 channels were compared between the two groups. The correlations between zALFF values and GDS scores were computed.Results:The zALFF values of the children with GDD were significantly lower than those of the HC in the right frontal pole (channel 10) and the right pre-motor and supplementary motor areas (channel 43). In contrast, the zALFF values in the left pre-motor and supplementary motor areas (channels 24 and 26) were significantly higher in the children with GDD compared to the HC. Spearman ranked correlation analysis revealed that the zALFF values in the right pre-motor and supplementary motor areas (channel 43) were positively correlated with socialization scores on the GDS ( r=0.37, P≤0.05). Conclusions:The delays in cognitive and motor development in children with GDD may be associated with functional abnormalities in the right frontal polar region and the bilateral premotor and supplementary motor areas. zALFF values from the right premotor and supplementary motor areas are positively correlated with social skills.
