Aerobic exercise improves the cardiopulmonary fitness and sleep quality and promotes ventricular remodeling in patients with pulmonary hypertension
10.3760/cma.j.cn421666-20241108-00860
- VernacularTitle:有氧运动对肺动脉高压患者右心室重塑、心肺适能及睡眠质量的影响
- Author:
Zhenyu ZHANG
1
;
Zhijun YANG
;
Jinhua YANG
;
Xiaoyang NIU
Author Information
1. 商丘师范学院体育学院，商丘 476000
- Publication Type:Journal Article
- Keywords:
Aerobic exercise;
Pulmonary hypertension;
Sleep quality;
Cardiopulmonary fitness;
Peak oxygen uptake
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2025;47(5):413-418
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effect of aerobic exercise on cardiopulmonary fitness, sleep quality, and right ventricular remodeling in patients with pulmonary arterial hypertension (PAH).Methods:Sixty stable PAH patients without regular exercise habits were randomly divided into an observation group and a control group according to a random number table. Both groups received standard targeted drug therapy, but the observation group additionally performed aerobic exercise three times per week for 12 weeks. Before and after the intervention, the Pittsburgh Sleep Quality Index (PSQI) was used to assess sleep quality, while echocardiography was performed to measure the end-diastolic volume (RVEDV), end-systolic volume (RVESV), stroke volume (RVSV), and ejection fraction (RVEF) of the participants′ right ventricles. In addition, cardiopulmonary exercise testing was conducted to obtain peak oxygen uptake (VO 2peak), peak heart rate (HR peak), peak work (W peak), and exercise time (ET). Results:In the observation group, the average scores of all items in the PSQI scale, as well as the echocardiography indicators of RVEDV and RVESV decreased significantly compared with before the intervention. VO 2peak, W peak and ET in the cardiopulmonary exercise test, as well as RVSV and RVEF had increased significantly. There was no significant change in HR peak, on average. There was also no significant change in any of these indicators in the control group, on average. The left the observation group′s average VO 2peak, W peak, ET, RVSV and RVEF significantly higher than in the control group, while their PSQI scale scores, RVEDV and RVESV were significantly lower. Conclusions:Regular aerobic exercise can improve sleep quality and promote cardiopulmonary fitness and right ventricular remodeling in PAH patients. That should tend to help reduce mortality, so such therapy is worthy of clinical promotion and application.
