Transcranial magnetic stimulation can relieve cognitive impairment induced by high-altitude hypoxia
10.3760/cma.j.cn421666-20240924-00786
- VernacularTitle:不同频率的高频重复经颅磁刺激对高原低氧环境下官兵认知功能减退的影响
- Author:
Zhesi CHEN
1
;
Xiaofei HUANG
;
Tian TIAN
;
Jinqi ZHENG
;
Li ZHENG
;
Xiaohua ZHAO
;
Yi HUANG
;
Dan YANG
;
Zesha LING
;
Dongliang GUO
;
Hao LIU
;
Baolian LIU
;
Mei CHEN
;
Ling BAI
;
Jiancheng LIU
;
Wenchun WANG
;
Rizhao PANG
Author Information
1. 西部战区总医院，成都 610083
- Publication Type:Journal Article
- Keywords:
Transcranial magnetic stimulation;
Cognition;
High-altitude hypoxia;
Hypoxia;
Event-related potentials
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2025;47(5):393-397
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effect of high-frequency repetitive transcranial magnetic stimulation (rTMS) at different frequencies on cognitive impairment due to high-altitude hypoxia.Methods:Sixty officers and soldiers displaying cognitive impairment in a hypoxic high-altitude environment were randomly divided into 15Hz, 20Hz and 25Hz groups, each of 20. They were given rTMS at those frequencies for 30 days. Before the stimulation and after 15 and 30 days, event-related potentials, latencies of mismatched negativity (MMN) and P300 signals were recorded. The participants′ cognition was also evaluated using the Montreal Cognitive Assessment Scale (MoCA). Correlation between the electrophysiological indexes and the MoCA scores was computed.Results:After 15 days, all had shorter MMN latencies, higher total MoCA scores and better memory scores. The only significant difference among the three groups was in the average memory scores. After 15 days, MMN latency was significantly negatively correlated with the memory scores in all three groups ( r=0.44 to -0.54). Conclusions:rTMS at frequencies above 15Hz can effectively relieve cognitive impairment, especially memory dysfunction, resulting from high-altitude hypoxia.
