Supplementing Denver model intervention with transcranial magnetic stimulation improves the treatment of young children with autism spectrum disorder
10.3760/cma.j.cn421666-20240829-00681
- VernacularTitle:早期介入丹佛模式干预联合重复经颅磁刺激治疗孤独症谱系障碍儿童的疗效观察
- Author:
Wei LI
1
;
Yanping TIAN
;
Yanmei LAI
;
Qinghong LI
;
Qiao SUN
;
Hong LI
;
Xin ZHANG
;
Zhihai LYU
Author Information
1. 深圳市龙岗区妇幼保健院(汕头大学医学院龙岗妇幼临床学院)儿童康复科，深圳 518100
- Publication Type:Journal Article
- Keywords:
Autism spectrum disorder;
Early Start Denver model;
Transcranial magnetic stimulation;
Childhood Autism Rating;
Autism
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2025;47(4):359-363
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe any effect of supplementing treatment according to the Early Start Denver model (ESDM) with repeated transcranial magnetic stimulation (rTMS) in the treatment of children with autism spectrum disorder (ASD).Methods:Sixty-seven children on the autism spectrum aged 2 or 3 years were randomly divided into a control group of 33 and an observation group of 34. Both groups were treated as specified by the ESDM for 24 weeks, but the observation group additionally received rTMS. At 12 and 24 weeks, both groups were evaluated using the Autism Behavior Checklist, the Childhood Autism Rating Scale (CARS), the revised version of the Repetitive Behavior Scale (RBS-R), Gesell Development Schedules, and the Autism Treatment Evaluation Checklist (ATEC).Results:The CARS, Gesell, RBS-R and ATEC results of both groups had improved significantly after 12 weeks, with further improvements observed another 12 weeks later, when the average Autism Behavior Checklist scores had also improved significantly. At that point the results of the observation group were significantly better than those of the control group, on average.Conclusions:Combining ESDM and rTMS can significantly relieve the main symptoms of autism and improve the comprehensive development of children on the autism spectrum 2 or 3 years old. Therefore, such combination is worthy of application in clinical practice.
