Clinical value of deep inspiration breath-hold SPECT pulmonary perfusion imaging
10.3760/cma.j.cn321828-20241225-00446
- VernacularTitle:深吸气屏气SPECT肺灌注显像的应用价值
- Author:
Chaoling JIN
1
;
Rongzheng MA
;
Ling WANG
;
Yumin ZHENG
Author Information
1. 中日友好医院核医学科，北京 100029
- Publication Type:Journal Article
- Keywords:
Lung diseases;
Respiration;
Artifacts;
Phantoms, imaging;
Tomography, emission-computed, single-photon;
Tomography, X-ray computed;
Technetium Tc 99m aggreg
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2025;45(7):421-424
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the feasibility and clinical application value of deep inspiration breath-hold SPECT pulmonary perfusion imaging (DBQ).Methods:Twenty-eight patients (15 males, 13 females, age (38±18) years) who had pulmonary diseases and visited China-Japan Friendship Hospital between September 2023 and February 2024 were prospectively included, including 18 pulmonary embolism cases, 5 chronic obstructive pulmonary disease cases, and 5 pulmonary interstitial fibrosis cases. All patients underwent DBQ, traditional pulmonary perfusion imaging (Q), and low-dose CT (LDCT). The acquisition parameters of DBQ were determined through National Electrical Manufactures Association (NEMA) International Electrotechnical Commission (IEC) phantom model research. The radioactive counts, three-dimensional registration error, and heterogeneity of DBQ and Q were compared using paired t test, while the comparison of detection rates for pulmonary embolism lesions was performed using McNemar test. Results:The radioactive counts of DBQ and Q were (3.6±0.6)×10 6 and (4.5±0.7)×10 6( t=2.48, P=0.018), respectively. In 18 patients with pulmonary embolism, compared with Q-LDCT, DBQ-LDCT detected 8 more lesions, thus increasing the detection rare (41 vs 33; χ2=8.69, P=0.004). Among the 28 patients, the registration errors between DBQ and LDCT vs Q and LDCT were (3.1±0.4) vs (8.2±0.8)mm ( t=3.82, P<0.001), respectively. The heterogeneity of DBQ was significantly different from that of Q (0.74±0.15 vs 0.85±0.11; t=2.38, P=0.029). Conclusion:DBQ shows better image quality and diagnostic effect than traditional perfusion imaging.
