Value of 11C-MET PET/MR imaging for the differential diagnosis between neoplastic and non-neoplastic brain lesions
10.3760/cma.j.cn321828-20240720-00268
- VernacularTitle:11C-MET PET/MR对脑肿瘤与非肿瘤性病变的鉴别诊断价值
- Author:
Yuanyuan XU
1
;
Chunyan LI
1
;
Fang LIU
1
;
Weiwei RUAN
1
;
Fan HU
1
;
Yongkang GAI
1
;
Xiaoli LAN
1
Author Information
1. 华中科技大学同济医学院附属协和医院核医学科、湖北省分子影像重点实验室，武汉 430022
- Publication Type:Journal Article
- Keywords:
Brain neoplasms;
Methionine;
Isotope labeling;
Carbon radioisotopes;
Positron-emission tomography;
Magnetic resonance imaging;
Diagnosis, differential
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2025;45(7):394-399
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the clinical value of 11C-methyl- L-methionine (MET) PET/MR in the differential diagnosis between neoplastic and non-neoplastic brain lesions. Methods:From July 2017 to May 2022, a total of 34 patients (19 males, 15 females, age 8-81 years) who received 11C-MET PET/MR imaging for suspected brain tumors in Union Hospital, Tongji Medical College, Huazhong University of Science and Technology were retrospectively enrolled. Postoperative pathological or clinical follow-up results were used as the gold standard. Diagnostic performance of 11C-MET PET/MR and contrast-enhanced MRI was evaluated by ROC curve analysis and Delong test, as well as the diagnostic performance of PET metabolic parameters (SUV and target to background ratio (TBR)), MRI multi-sequence parameters (cerebral blood flow (CBF), relative CBF (rCBF), apparent diffusion coefficient (ADC), relative ADC (rADC), choline/creatine (Cho/Cr) and choline/ N-acetylaspartate (Cho/NAA)) and their combination. Results:A total of 35 lesions of 34 patients were enrolled, including 12 (34.3%) non-neoplastic lesions and 23(65.7%) neoplastic lesions. The diagnostic sensitivity, specificity, and accuracy for 11C-MET PET/MR were 91.3%(21/23), 12/12, and 94.3%(33/35), in contrast to 16/18, 2/10, and 64.3%(18/28) for contrast-enhanced MRI. Maximum TBR (TBR max) showed the highest discriminative value (AUC=0.877, 95% CI: 0.692-1.000). The combination of TBR max, minimum ADC (ADC min), rCBF, and Cho/NAA could achieve a higher diagnostic performance (AUC=0.918, 95% CI: 0.816-1.000), although the difference was not statistically significant ( Z=-0.42, P=0.676). Conclusion:Multiple quantitative parameters of 11C-MET PET/MR are beneficial to distinguish neoplastic from non-neoplastic brain lesions, and their combination may improve the diagnostic confidence.
