Differential diagnostic value of 18F-FDG PET/CT combined with MRI in breast cancer: ductal carcinoma in situ and early stage invasive ductal carcinoma
10.3760/cma.j.cn321828-20240826-00307
- VernacularTitle:18F-FDG PET/CT联合MRI在鉴别乳腺导管原位癌及早期浸润性导管癌中的价值
- Author:
Yumeng JIANG
1
;
Wenwen JIANG
;
Cuiyu LIU
;
Fei JIN
;
Chaowei LI
;
Lei ZENG
;
Na FANG
;
Jinxing LIU
;
Yanli WANG
Author Information
1. 青岛大学青岛医学院，青岛 266000
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Carcinoma, intraductal, noninfiltrating;
Carcinoma, ductal, breast;
Positron-emission tomography;
Tomography, X-ray computed;
Fluorodeoxy
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2025;45(10):600-605
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the value of 18F-FDG PET/CT combined with MRI in the diagnosis and differential diagnosis of ductal carcinoma in situ (DCIS) and early stage invasive ductal carcinoma (IDC). Methods:From September 2019 to December 2023, 12 patients with DCIS (all females; age 36-67 years) and 34 patients with early stage IDC (all females; age 36-73 years) in Qingdao Central Hospital were retrospectively analyzed. The general clinical information, MRI features, and 18F-FDG PET/CT features of patients were analyzed. χ2 test, Fisher exact test, and Mann-Whitney U test were used to analyze the data. The independent predictors of DCIS were analyzed by logistic regression analysis. The value of different indicators in diagnosing DCIS was analyzed using ROC curves analysis, and Delong test was used to assess the differences among AUCs. Results:The differences in tumor metabolic volume (MTV; 18.55(10.90, 76.30) vs 4.00(2.00, 11.45)cm 3) and total lesion glycolysis (TLG; 44.85(25.30, 125.30) vs 9.40(6.68, 22.35)g) of breast lesion, enhancement pattern (non-mass enhancement (NME); 8/12 vs 29.4%(10/34)), lobulation sign (0/12 vs 58.8%(20/34)), and apparent diffusion coefficient (ADC; 1.33 (1.16, 1.63)×10 -3vs 1.08 (0.75, 1.28)×10 -3mm 2/s) between DCIS and early stage IDC groups were statistically significant ( Z values: from -3.91 to -2.56, χ2=5.17, all P<0.05). When differentiating DCIS from early stage IDC, NME (odds ratio ( OR)=36.50, 95% CI: 2.15-618.52, P=0.013), ADC ( OR=7.85, 95% CI: 1.11-55.46, P=0.044), and TLG ( OR=1.06, 95% CI: 1.02-1.11, P=0.007) were independent predictors. The AUC of the three predictors combination was 0.941, which was higher than those of single predictors ( Z values: 2.00-2.80, P values: 0.005-0.046). Conclusion:The combination of 18F-FDG PET/CT and MRI improves the efficacy of differential diagnosis between DCIS and early stage IDC, thereby providing a basis for developing personalized treatment plans for patients.
