Relation of aortic arch calcification volume measured by SPECT/CT with hungry bone syndrome in patients with renal secondary hyperparathyroidism after parathyroidectomy
10.3760/cma.j.cn321828-20240710-00253
- VernacularTitle:基于SPECT/CT主动脉弓钙化体积与慢性肾脏病继发性甲状旁腺功能亢进症术后骨饥饿综合征的关系
- Author:
Zejun CHEN
1
;
Qing SHAO
;
Qianhuan HUANG
;
Chaoqun WU
;
Feng WANG
;
Bin ZHOU
Author Information
1. 南通大学附属江阴医院核医学科，无锡 214400
- Publication Type:Journal Article
- Keywords:
Hyperparathyroidism, secondary;
Vascular calcification;
Renal insufficiency, chronic;
Tomography, emission-computed, single-photon;
Tomography, X-ray comp
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2025;45(8):488-492
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To access the relation of aortic arch calcification (AoAC) volume based on parathyroid SPECT/CT imaging with hungry bone syndrome (HBS) in patients with renal secondary hyperparathyroidism (SHPT) after parathyroidectomy (PTX).Methods:From June 2015 to May 2024, the imaging and clinical data of 89 renal SHPT patients (52 males, 37 females, age: (51.5±10.3) years) who underwent parathyroid 99Tc m-methoxyisobutylisonitrile (MIBI) SPECT/CT in Affiliated Jiangyin Hospital of Nantong University were retrospectively analyzed. The AoAC volume was measured by Volume software of SPECT/CT system. The patients were divided into HBS group and non-HBS group, and the independent-sample t test, Mann-Whitney U test were used to compare differences of various indicators between the two groups. Logistic regression was used to analyze the influencing factors of HBS. Results:All 89 patients underwent PTX successfully, 50 patients (56.2%) were with HBS and 39 patients (43.8%) were not. The differences of age ((47.9±9.9) vs (56.1±9.0) years, t=-3.98, P<0.001), AoAC volume (0.36(0.02, 1.30) vs 1.57(0.37, 3.77)cm 3, Z=-3.17, P=0.002), preoperative alkaline phosphatase (ALP) (345.75(218.50, 632.50) vs (203.13±114.57)U/L, Z=-4.69, P<0.001), preoperative parathyroid hormone (147.85(109.83, 227.40) vs (135.58±51.14)pmol/L, Z=-2.34, P=0.019) and preoperative serum corrected calcium ((2.38±0.21) vs 2.54(2.39, 2.62)mmol/L, Z=-3.09, P=0.002) between HBS group and non-HBS group were significant. Logistic regression analysis showed that the AoAC volume ((odds ratio, OR)=0.628, 95% CI: 0.427-0.924, P=0.018), preoperative ALP ( OR=1.007, 95% CI: 1.002-1.012, P=0.010) and preoperative serum corrected calcium ( OR=0.041, 95% CI: 0.003-0.545, P=0.016) were independent risk factors for HBS. Conclusion:The AoAC volume measured by preoperative SPECT/CT can be used for an effective criteria of evaluating HBS in patients with renal SHPT after PTX, and AoAC volume may be one of independent risk factors for HBS.
