Association between the outcome of anti-leucine-rich glioma-inactivated protein 1 antibody-related encephalitis and the characteristics of brain glucose metabolism
10.3760/cma.j.cn321828-20241231-00450
- VernacularTitle:抗富含亮氨酸胶质瘤失活蛋白1抗体相关脑炎的转归与脑葡萄糖代谢特征的相关性研究
- Author:
Jingjie GE
1
;
Jingguo WANG
;
Xiangjun CHEN
;
Yunhao YANG
;
Huamei LIN
;
Bo DENG
;
Jing WANG
;
Quanling JIANG
;
Yihui GUAN
;
Chuantao ZUO
Author Information
1. 复旦大学附属华山医院核医学/PET中心，上海 200235
- Publication Type:Journal Article
- Keywords:
Autoimmune diseases of the nervous system;
Encephalitis;
Antibodies;
Intracellular signaling peptides and proteins;
Positron-emission tomography;
Fluorodeo
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2025;45(4):206-211
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the potential value of cerebral glucose metabolism characteristics in anti-leucine-rich glioma-inactivated protein 1 (LGI1) antibody-related encephalitic patients during acute phase as the clinical indicator of disease outcomes.Methods:From October 2019 to December 2023, 28 patients (18 males, 10 females; age (56.6±11.9) year) with anti-LGI1 antibody-related encephalitis diagnosed at Huashan Hospital, Fudan University were prospectively enrolled. All patients received baseline brain 18F-FDG PET imaging and were divided into different subgroups according to the prognosis (good prognosis and poor prognosis groups) and recurrence (recurrence and non-recurrence groups) after follow-up. The difference of Montreal Cognitive Assessment (MoCA) score between the two groups was compared by Mann-Whitney U test. Statistical parametric mapping (SPM) analysis was used to analyze the PET images of different groups by independent-sample t test, and the characteristics of cerebral glucose metabolism of patients with different outcomes were obtained. Results:MoCA scores between the recurrence group ( n=6) and the non-recurrence group ( n=22; 14.0(9.8, 20.5) vs 22.0(18.0, 24.0); Z=2.17, P=0.030), and between the poor prognosis group ( n=13) and the good prognosis group ( n=15; 14.0(10.0, 22.0) vs 22.0(19.8, 25.3); Z=2.47, P=0.013) were significantly different. Compared with the good prognosis group, the cerebral glucose metabolism in the poor prognosis group was decreased in the bilateral frontal lobe, lateral temporal lobe, inferior parietal lobule and cingulate gyrus, but increased in the brainstem, bilateral lentiform nucleus and bilateral paracentral lobule/postcentral gyrus (all t=1.71, all P<0.05). Compared with the non-recurrence group, the metabolism of bilateral medial frontal gyrus, anterior cingulate gyrus, bilateral insula, superior temporal gyrus and thalamus decreased in the recurrence group, while the metabolism of bilateral precentral gyrus, inferior frontal gyrus and bilateral lentiform nucleus increased (all t=1.71, all P<0.05). Conclusion:18F-FDG PET imaging reveals the differences in brain metabolism of anti-LGI1 antibody-related encephalitic patients at baseline with different outcomes (prognosis, recurrence or not), which can provide a new perspective for the clinical evaluation of the disease at baseline.
