A two-sample Mendelian randomization study of the association between type 2 diabetes mellitus and papillary thyroid cancer
10.3760/cma.j.cn321828-20240528-00180
- VernacularTitle:2型糖尿病与甲状腺乳头状癌关系的两样本孟德尔随机化研究
- Author:
Jiawen WANG
1
;
Qiuyu LIN
1
;
Nan JIANG
1
;
Shuangyan ZHAO
1
;
Yuxin WANG
1
;
Ying GUO
1
;
Chenghe LIN
1
Author Information
1. 吉林大学第一医院核医学科，长春 130021
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus, type 2;
Thyroid neoplasms;
Carcinoma, papillary;
Mendelian randomization analysis
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2025;45(3):164-168
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the causal relationship between type 2 diabetes mellitus (T2DM), type 1 diabetes mellitus (T1DM), body mass index (BMI) and papillary thyroid cancer using Mendelian randomization(MR) study.Methods:Publicly available genome-wide association studies (GWAS) were used as the data source to screen single nucleotide polymorphisms significantly associated with exposure factors (instrumental variables), and the inverse variance weighting (IVW), weighted median, MR-Egger analysis, simple mode, and weighted mode of two-sample MR were used to assess the causal association between T2DM, T1DM, BMI and papillary thyroid cancer. The reliability and stability of the results were assessed by heterogeneity analysis, multiple validity analysis and sensitivity analysis.Results:A total of 118 strong instrumental variables for T2DM, 76 for T1DM, and 486 for BMI were screened respectively to conduct two-sample MR analysis. Among the 5 MR analysis methods, the results of the IVW method showed that T2DM was significantly associated with papillary thyroid cancer (odds ratio ( OR)=1.147, 95% CI: 1.026-1.282; P=0.016), and the genetic effect values ( β values) of the other 4 analysis methods and IVW method were in the same direction; the results of heterogeneity analysis, multiplicity analysis and sensitivity analysis showed all P>0.05. T1DM (IVW method: OR=1.000, 95% CI: 0.952-1.051; P=0.994) and papillary thyroid cancer, BMI (IVW method: OR=1.214, 95% CI: 0.923-1.598; P=0.166) and papillary thyroid cancer were not clearly causally related. Conclusions:There is a causal association between T2DM and papillary thyroid cancer, and T2DM increases the risk of papillary thyroid cancer. There is no clear causal association between T1DM, BMI and papillary thyroid cancer.
