Exploring the optimal timing of preoperative 99Tc m-MIBI SPECT/CT imaging in different types of hyperparathyroidism
10.3760/cma.j.cn321828-20240527-00177
- VernacularTitle:不同类型甲状旁腺功能亢进症术前行 99Tc m-MIBI SPECT/CT断层显像最佳时机探索
- Author:
Yichi XIE
1
;
Weiwei KONG
1
;
Jiaxi YOU
1
;
Ning WANG
1
;
Yirong ZHU
1
;
Zhihui HONG
1
;
Yizhen SHI
1
Author Information
1. 苏州大学附属第二医院核医学科，苏州 215004
- Publication Type:Journal Article
- Keywords:
Hyperparathyroidism;
Technetium Tc 99m sestamibi;
Tomography, emission-computed, single-photon;
Tomography, X-ray computed
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2025;45(3):159-163
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the diagnostic efficacy of the added 99Tc m-methoxyisobutylisonitrile (MIBI) SPECT/CT imaging (tomography imaging) after early or delayed planar imaging in different types of hyperparathyroidism, and to seek for the optimal timing of preoperative imaging. Methods:A total of 339 patients (148 males, 191 females, age (52±13) years) with primary or secondary hyperparathyroidism and pathological results from January 2016 to June 2024 in the Second Affiliated Hospital of Soochow University were retrospectively analyzed. The patients were divided into primary early tomography imaging group ( n=63) and delayed tomography imaging group ( n=47), secondary early tomography imaging group ( n=89) and delayed tomography imaging group ( n=140). χ2 test was used to compare the diagnostic efficacies of early and delayed tomography imaging. Results:The difference of accuracy between primary delayed (98.40%(185/188)) and early tomography imaging (94.84%(239/252)) was statistically significant ( χ2=3.90, P=0.048). There were significant differences in sensitivity (77.29%(405/524) and 85.40%(275/322)), accuracy (75.89%(425/560) and 83.99%(299/356)) and negative predictive value (14.39%(20/139) and 33.80%(24/71)) between secondary delayed and early tomography imaging ( χ2 values: 8.33, 8.61, 10.70, all P<0.01). Conclusion:The optimal timing of preoperative 99Tc m-MIBI SPECT/CT imaging for primary and secondary hyperparathyroidism is after delayed planar imaging and after early planar imaging respectively.
