Indolent leukemic non-nodal mantle cell lymphoma with TP53 mutation misdiagnosed as chronic lymphocytic leukemia: a case report and literature review
10.3760/cma.j.cn121090-20241205-00538
- VernacularTitle:误诊为慢性淋巴细胞白血病的伴TP53基因突变的惰性白血病性非淋巴结型套细胞淋巴瘤1例报告并文献复习
- Author:
Tonglu QIU
1
;
Yaping ZHANG
;
Yan WANG
;
Yujie WU
;
Wenyu SHI
;
Yi XIA
Author Information
1. 南京医科大学第一附属医院，江苏省人民医院血液科、淋巴瘤中心，南京医科大学血液研究重点实验室，江苏省肿瘤个体化医学协同创新中心，南京 210029
- Publication Type:Journal Article
- From:
Chinese Journal of Hematology
2025;46(2):174-178
- CountryChina
- Language:Chinese
-
Abstract:
Patients with leukemic non-nodal mantle cell lymphoma (nnMCL) typically exhibit an indolent clinical course, and when asymptomatic and without treatment indications, a watchful observation follow-up can be adopted. This article presents a retrospective summary of a case of nnMCL, misdiagnosed as chronic lymphocytic leukemia (CLL) and carrying a TP53 mutation, along with a literature review. The case highlights the importance of differential diagnosis between nnMCL and CLL, and suggests that for nnMCL patients, the presence of high-risk biological markers such as TP53 mutations does not necessarily indicate an immediate need for treatment; rather, a strict watch-and-wait strategy may be a more appropriate option.
