Research progress on estimating internal radiation dose of radiopharmaceuticals for targeted α radionuclide therapy in preclinical evaluation
10.3760/cma.j.cn321828-20240126-00037
- VernacularTitle:靶向α核素治疗药物临床前评价中内照射剂量估算的研究进展
- Author:
Xufu CHEN
1
;
Jie GAO
;
Zhaolong WANG
;
Haili LU
;
Shu ZHANG
;
Zongtai HAN
;
Jianguo LI
Author Information
1. 中国辐射防护研究院放射医学与环境医学研究所、国家原子能机构（CAEA）核技术（放射性药物非临床评价）研发中心、中核放射毒理与放射性药物临床前评价重点实验室、药物毒理及放射性药物临床前研究山西省重点实验室，太原 030006
- Publication Type:Journal Article
- Keywords:
Radiotherapy;
Alpha particles;
Radiation dosage;
Trends
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2025;45(1):57-60
- CountryChina
- Language:Chinese
-
Abstract:
Due to the specificity of radiopharmaceuticals for targeted α radionuclide therapy, such as radioactivity and radiation damage risk, it is necessary to estimate the internal radiation dose in preclinical evaluation to correctly evaluate the efficacy and safety of the drug, as well as in subsequent clinical studies. This review illustrates current research status of estimating internal radiation dose of targeted α radionuclide therapeutic radiopharmaceuticals based on preclinical studies, in order to add insights for understanding estimation of radiopharmaceuticals internal radiation dose and provide reference for the preclinical evaluation of radiopharmaceuticals.
