The state of the art: diagnosis and therapeutic interventions of clonal hematopoiesis of indeterminate potential and clonal cytopenias of undetermined significance
10.3760/cma.j.cn121090-20241228-00600
- VernacularTitle:重视潜质未定的克隆性造血和意义未定的克隆性血细胞减少症的诊断和治疗
- Author:
Zhijian XIAO
1
Author Information
1. 中国医学科学院血液病医院（中国医学科学院血液学研究所），血液与健康全国重点实验室，国家血液系统疾病临床医学研究中心，细胞生态海河实验室，天津 300020
- Publication Type:Journal Article
- Keywords:
Clonal hematopoiesis;
Clonal hematopoiesis of indeterminate potential;
Clonal cytopenias of undetermined significance;
Diagnosis;
Treatment
- From:
Chinese Journal of Hematology
2025;46(1):5-8
- CountryChina
- Language:Chinese
-
Abstract:
Clonal hematopoiesis of indeterminate potential (CHIP) and clonal cytopenias of undetermined significance (CCUS) are included in both fifth edition of the World Health Organization classification (WHO 2022) and International Consensus Classification (ICC). Recently three models were developed for prediction of myeloid neoplasms risk and clinical trials are initiated to investigate potential treatments for CHIP and CCUS. Challenges in diagnosis and therapeutic intervention of CHIP and CCUS were discussed.
