Acute myeloid leukemia with translocation t (8;16) (p11;p13) and prominent coagulation abnormalities at onset: case report and review of literature
10.3760/cma.j.cn121090-20241130-00503
- VernacularTitle:显著出凝血异常起病的t（8;16）（p11;p13）急性髓系白血病1例报告并文献复习
- Author:
Jiawen DAI
1
;
Feng XUE
;
Wei LIU
;
Lei ZHANG
;
Renchi YANG
;
Xiaofan LIU
Author Information
1. 中国医学科学院血液病医院（中国医学科学院血液学研究所），血液与健康全国重点实验室，国家血液系统疾病临床医学研究中心，细胞生态海河实验室，天津市血液病基因治疗研究重点实验室，中国医学科学院血液病基因治疗重点实验室，天津 300020
- Publication Type:Journal Article
- From:
Chinese Journal of Hematology
2024;45(S1):73-76
- CountryChina
- Language:Chinese
-
Abstract:
Acute Myeloid Leukemia with t (8;16) (p11;p13) is a rare subtype of AML. This article presents a retrospective analysis of a 19-year-old female patient with t (8;16) (p11;p13) AML, focusing on her clinical features and treatment course, alongside a review of relevant literature. The patient was admitted due to skin ecchymosis and gastrointestinal bleeding, rapidly progressing to disseminated intravascular coagulation. Bone marrow examination revealed an abnormal blast morphology resembling early promyeloblasts, and the initial diagnosis was acute promyelocytic leukemia. However, chromosomal analysis identified the t (8;16) (p11.2;p13.3) translocation. The patient was finally diagnosed with acute monocytic leukemia. Following intensive induction chemotherapy, she achieved complete remission, but relapse occurred during consolidation therapy. The overall prognosis was poor. AML with t (8;16) (p11;p13) is relatively rare and characterized by distinct clinical and laboratory features, with a generally unfavorable prognosis. Early recognition by clinicians is crucial for appropriate management.
