Nonspecific peripheral T cell lymphoma combined with pure red cell aplasia: a case report and literature review

VernacularTitle:外周T细胞淋巴瘤非特指型合并纯红细胞再生障碍1例报告并文献复习
Author: Xueya ZHANG ¹ ; Yuyu ZHENG ; Dage FAN ; Jinfa ZHONG ; Shixin WU
Author Information

1. 福建医科大学附属第二医院血液科，泉州　362000
Publication Type:Journal Article
From: Chinese Journal of Hematology 2025;46(4):359-362
CountryChina
Language:Chinese
Abstract: Nonspecific peripheral T-cell lymphoma (PTCL-NOS) combined with pure red cell aplasia (PRCA) is reported by only few in China. This article described a patient with PTCL-NOS who presented with severe anemia as the initial symptom, accompanied by multiple lymphadenopathy. Laboratory tests confirmed decreased red blood cell count and reticulocyte proportion, markedly reduced bone marrow red blood cell proliferation, and markedly increased proportion of bone marrow CD3 +CD8 + T lymphocytes. On lymph node pathology examination, immunohistochemistry was consistent with PTCL-NOS, with positive TCRβ gene rearrangement. First-line chemotherapy with four courses of ECHOP regimen led to significant reductions in lymph node size, partial remission on whole-body computed tomography evaluation, normalization of hemoglobin and bone marrow hematopoietic erythroid proliferation, and absence of CD3 +CD8 + T lymphocytes in bone marrow. Currently, the patient remains to have good prognosis with maintenance oral lenalidomide.