Post-traumatic acquired hemophilia A: a case report and literature review

VernacularTitle:创伤后获得性血友病A：1例报告并文献复习
Author: Yanyan XIE ¹ ; Meirong YANG ; Mingzhu ZHANG ; Zhaoling DENG ; Linhong WANG ; Jinyu LI ; Junjian ZHAO ; Baolai HUA ; Zhenyu YAN
Author Information

1. 华北理工大学附属医院血液科，唐山　063000
Publication Type:Journal Article
From: Chinese Journal of Hematology 2024;45(S1):100-103
CountryChina
Language:Chinese
Abstract: Acquired Hemophilia A is an acquired bleeding disorder characterized by reduced FⅧ activity due to the presence of autoantibodies against anticoagulant factor Ⅷ in the circulation. Laboratory tests are typically characterized by prolonged isolated activated partial thromboplastin time (APTT). Clinically, it often manifests as severe bleeding, and 50% of AHA patients can identify the cause. This article reports on a patient with post-traumatic AHA who rapidly improved after antibody removal and bypass replacement therapy, followed by wound healing following surgical intervention. A review of relevant literature is also conducted to enhance clinicians' awareness of AHA, which presents with normal coagulation initially and gradually develops into prolonged APTT accompanied by bleeding manifestations, aiming for early diagnosis and timely treatment.