A case report of acquired factor ⅩⅢ deficiency following hip replacement surgery induced by sodium valproate and a literature review
10.3760/cma.j.cn121090-20241130-00514
- VernacularTitle:丙戊酸钠致髋关节置换术后获得性凝血因子ⅩⅢ缺乏症1例报告及文献复习
- Author:
Minxia ZHANG
1
;
Huan BAI
;
Ning TANG
;
Zhenya HONG
;
Weikai ZHANG
Author Information
1. 华中科技大学同济医学院附属同济医院检验科，武汉 430030
- Publication Type:Journal Article
- From:
Chinese Journal of Hematology
2024;45(S1):110-113
- CountryChina
- Language:Chinese
-
Abstract:
Coagulation factor ⅩⅢ (FⅩⅢ) deficiency is a rare disease that is easily overlooked because routine coagulation tests do not reflect its deficiency. FⅩⅢ deficiency is divided into hereditary FⅩⅢ deficiency and acquired FⅩⅢ deficiency. The diagnosis of FⅩⅢ deficiency requires testing for FⅩⅢ activity and antigen, with confirmation through genetic testing. Due to the instability of fibrin clots caused by FⅩⅢ deficiency, the clinical features of FⅩⅢ deficiency include umbilical cord bleeding, soft tissue hematoma, recurrent miscarriage, cerebral hemorrhage, and delayed wound healing. Acquired FⅩⅢ deficiency can be caused by various reasons, and this article introduces a case of acquired FⅩⅢ deficiency in a patient after hip replacement surgery due to long-term use of sodium valproate.
