Acute promyelocytic leukemia with disseminated intravascular coagulation: a case report and literature review

VernacularTitle:急性早幼粒细胞白血病合并弥散性血管内凝血1例报告并文献复习
Author: Wenjing GU ¹ ; Rongfeng FU ; Lei ZHANG ; Renchi YANG ; Xiaofan LIU
Author Information

1. 中国医学科学院血液病医院（中国医学科学院血液学研究所），血液与健康全国重点实验室，国家血液系统疾病临床医学研究中心，细胞生态海河实验室，天津　300020
Publication Type:Journal Article
From: Chinese Journal of Hematology 2024;45(S1):85-88
CountryChina
Language:Chinese
Abstract: Acute promyelocytic leukemia (APL) is characterized by an aggressive onset and rapid progression. During induction chemotherapy, it is prone to being complicated by disseminated intravascular coagulation (DIC), which is a leading cause of early death in patients. This study reports a case of APL complicated by DIC during induction therapy with all-trans retinoic acid (ATRA) combined with arsenic trioxide (ATO). The patient's coagulopathy was corrected through active transfusion of blood products and replacement therapy with coagulation factors. Subsequently, complete remission was achieved after multiple courses of chemotherapy. This article provides a detailed description of the patient’s disease onset and treatment process, exploring the differences in pathogenesis, clinical presentation, and treatment strategies between APL-associated DIC and DIC caused by other diseases, alongside a review of the relevant literature.