Acute fatty liver of pregnancy with severe coagulopathy: a case report and review
10.3760/cma.j.cn121090-20241130-00509
- VernacularTitle:并发严重凝血障碍的妊娠期急性脂肪肝1例及文献复习
- Author:
Xin ZHANG
1
;
Hongbin MENG
1
;
Xianglin MENG
1
;
Lin CUI
1
;
Rongyi CAO
1
;
Liying CAI
1
Author Information
1. 哈尔滨医科大学附属第一医院产科，哈尔滨 150001
- Publication Type:Journal Article
- From:
Chinese Journal of Hematology
2024;45(S1):77-81
- CountryChina
- Language:Chinese
-
Abstract:
Acute fatty liver in pregnancy (Acute fatty liver of pregnancy, AFLP) in pregnancy is a relatively rare critical condition in obstetrics, which is difficult to distinguish in the early stages due to the non-specificity of its clinical manifestations. However, early recognition and timely termination of pregnancy is significant for the treatment of AFLP and is crucial to reduce mortality.This paper will report in detail a patient with AFLP at 37 weeks' gestation, mainly presenting with nausea and vomiting for 1 week and yellow skin for 2 days.Due to the relatively long course of the disease, the patient suffered a regrettable result of fetal death after emergency admission, and severe coagulation dysfunction, pulmonary edema, and pancreatitis occurred.The multidisciplinary team from the department of anesthesiology, ICU, hematology, blood transfusion department and so on, actively corrected coagulation disorders and multiple organ injuries in the emergency termination of pregnancy, and the patient had a good prognosis.The importance of early identification for the treatment of AFLP patients can be demonstrated, and the changes of coagulation function can be closely monitored to guide clinical treatment.
