Application of passive immunotherapies for post-traumatic tetanus: a review
10.3760/cma.j.cn501098-20250508-00264
- VernacularTitle:创伤后破伤风被动免疫制剂应用的研究进展
- Author:
Wei GUO
1
;
Zijing LIANG
;
Chuanlin WANG
Author Information
1. 广州医科大学附属第一医院急诊科，广州 510120
- Publication Type:Journal Article
- Keywords:
Tetanus;
Immunization, passive;
Antibodies, monoclonal
- From:
Chinese Journal of Trauma
2025;41(9):918-924
- CountryChina
- Language:Chinese
-
Abstract:
Tetanus is a potentially life-threatening neurological condition, and the prevention and treatment of post-traumatic tetanus remain the primary focus. which remains a significant public health challenge at present. In China, because tetanus booster vaccination is not yet widespread among adults, post-traumatic treatment and prophylaxis predominantly rely on passive immunotherapies for tetanus. Conventional passive immunizing agents include equine-derived tetanus antitoxin (TAT) and human tetanus immunoglobulin (HTIG). Although TAT remains widely used domestically, it is not recommended by the World Health Organization (WHO) due to safety concerns, while HTIG faces supply constraints and potential risks of pathogen transmission. The recent approval of the world′s first recombinant anti-tetanus toxin monoclonal antibody, developed through genetic recombination technology, offers a promising alternative to HTIG and TAT in clinical practice. This innovative agent has the potential to provide safer, more effective, and accessible tetanus prevention globally. To deepen the understanding of research progress in clinical applications of existing passive immunizing agents for tetanus, the authors reviewed the current application status of conventional agents and explored the key technical characteristics, neutralizing antigenic epitopes, and clinical application of the novel recombinant anti-tetanus toxin monoclonal antibody for passive immunotherapy for tetanus, providing scientific reference to improve the rational use of these agents and standardize post-traumatic tetanus prevention and treatment practices.
