Blood-spinal cord barrier repair strategies based on endothelial cells and junction structures after spinal cord injury: a review
10.3760/cma.j.cn501098-20250317-00138
- VernacularTitle:脊髓损伤后基于内皮细胞及其连接结构的血-脊髓屏障修复方案研究进展
- Author:
Zongze YANG
1
;
Yuchen ZHOU
;
Heng WANG
;
Tao XU
;
Cheng CHEN
;
Xiaoqing CHEN
Author Information
1. 南通大学附属医院脊柱外科，南通 226001
- Publication Type:Journal Article
- Keywords:
Spinal cord injuries;
Endothelial cells;
Tight junctions;
Adherens junctions;
Blood-spinal cord barrier
- From:
Chinese Journal of Trauma
2025;41(9):894-902
- CountryChina
- Language:Chinese
-
Abstract:
Spinal cord injury is a highly disabling central nervous system disorder whose pathological progression is closely associated with blood-spinal cord barrier (BSCB) disruption. Physical trauma to the spine or spinal cord may compromise BSCB integrity, triggering secondary damage including spinal edema, hemorrhage, oxidative stress, and excessive inflammatory responses. For the pivotal role of protecting the spinal cord microenvironment, the repair of BSCB is crucial in the treatment of spinal cord injury. Although present studies have explored BSCB repair strategies such as biological factor regulation, biomaterial applications, and traditional Chinese medicine interventions, most studies focus on improving the overall barrier function and fail to systematically elucidate how these strategies target the core functional units of BSCB, namely the endothelial cells and their junction structures, to achieve functional and structural restoration of the barrier. Therefore, the authors reviewed the composition and key repair targets of BSCB, along with research advances in BSCB repair strategies based on endothelial cells and junction structures, aiming to provide insights for basic research and clinical treatment of spinal cord injury.
