Dysregulated microenvironment and homeostasis remodeling strategies after spinal cord injury
10.3760/cma.j.cn501098-20250421-00243
- VernacularTitle:脊髓损伤微环境紊乱及稳态重塑策略
- Author:
Shujie ZHAO
1
;
Guoyong YIN
Author Information
1. 南京医科大学第一附属医院骨科，南京 210029
- Publication Type:Journal Article
- Keywords:
Spinal cord injuries;
Regeneration;
Tissue engineering;
Cellular microenvironment
- From:
Chinese Journal of Trauma
2025;41(9):819-823
- CountryChina
- Language:Chinese
-
Abstract:
Spinal cord injury is characterized by high mortality and disability rates, posing a major challenge to global medicine. Microenvironmental disruption represents a critical pathological feature of spinal cord injury, closely associated with disease progression and prognosis. Elucidating the dysregulated microenvironment and developing strategies to restore its homeostasis are crucial for improving the efficacy of spinal cord repair. Addressing the question of how to reestablish microenvironmental homeostasis, the authors analyzed cellular heterogeneity within the microenvironment, summarized recent advances in targeted microenvironment remodeling, and discussed current challenges and future directions, so as to provide new perspectives for the treatment of spinal cord injury.
