Application modes of human amniotic membrane in the treatment of central nerve injuries: a review
10.3760/cma.j.cn501098-20250418-00231
- VernacularTitle:人羊膜治疗中枢神经损伤应用方式的研究进展
- Author:
Yuchen ZHOU
1
;
Wei HAN
;
Tao XU
Author Information
1. 盐城市大丰人民医院骨科，盐城 224100
- Publication Type:Journal Article
- Keywords:
Amnion;
Spinal cord injuries;
Brain injuries;
Nerve regeneration;
Organizational engineering materials
- From:
Chinese Journal of Trauma
2025;41(10):1015-1020
- CountryChina
- Language:Chinese
-
Abstract:
Central nerve injuries, most commonly caused by traffic accidents or falls, frequently result in irreversible deficits such as paralysis, cognitive impairment and respiratory failure, profoundly impairing patients′ life quality and even proving to be fatal. Current therapeutic strategies including early surgical decompression, corticosteroid administration and neurotrophic pharmacotherapy fail to restore the neuro-homeostatic balance and systemic function. In recent years, biomaterial-based interventions have emerged as a promising alternative for central nerve injuries. Among them, the human amniotic membrane (HAM), a placental basement-membrane scaffold rich in collagen, hyaluronic acid and a cocktail of growth factors, perfectly combines angiogenic, anti-fibrotic and neurotropic properties that meet the complex demands of central nerve repair. Nevertheless, HAM-based therapies for central nerve injuries remain at an early stage of pre-clinical investigation. In the meantime, most studies have simply translated protocols validated for peripheral nerve injuries without addressing the pathological microenvironment specific to central nerve injuries. To this end, the authors reviewed recent advances in the modes of HAM application for central nerve injuries, aiming to provide novel insights and reference for future research on central nerve injuries.
