Impact of mitochondrial quality control imbalance on post-traumatic organ dysfunction: a review
10.3760/cma.j.cn501098-20240912-00556
- VernacularTitle:线粒体质量控制失衡对创伤后器官功能障碍影响的研究进展
- Author:
Anjing LU
1
;
Yuanlan LU
;
Jing LIU
;
Ruilie WANG
;
Guang YANG
;
Jin WU
;
Shuhong WANG
;
Changqiang LIANG
Author Information
1. 遵义医科大学附属医院急诊科，遵义 563003
- Publication Type:Journal Article
- Keywords:
Wounds and injuries;
Multiple organ failure;
Mitochondria
- From:
Chinese Journal of Trauma
2025;41(2):212-218
- CountryChina
- Language:Chinese
-
Abstract:
Trauma can disrupt the body′s internal environment, resulting in organ dysfunction. This may manifest as symptoms such as acute respiratory distress, liver and kidney dysfunction, circulatory disorders and neurological damage. Mitochondrial quality control (MQC), encompassing processes like autophagy, dynamic changes, and biogenesis, plays an essential role in maintaining mitochondrial function. Stress responses following trauma can cause mitochondrial dysfunction and MQC imbalance, thereby exacerbating organ injury. Correcting MQC imbalance can improve organ function. Current researches on MQC in post-traumatic organ dysfunction mainly focuses on imbalance in specific MQC mechanism, lacking a systemic understanding of its incidence and progression. To this end, the authors reviewed the progress in researches on the impact of MQC imbalance on post-traumatic organ dysfunction, aiming to provide insights for clinical treatment.
