Mechanisms, assessment and intervention in vascular aging
10.3760/cma.j.issn.0254-9026.2025.08.005
- VernacularTitle:血管衰老的机制、评估和干预
- Author:
Le ZHANG
1
;
Cuntai ZHANG
Author Information
1. 华中科技大学同济医学院附属同济医院老年医学科，武汉 430030
- Publication Type:Journal Article
- Keywords:
Aging;
Vascular diseases;
Clinical assessment and intervention;
Expert consensus;
Standardized assessment and intervention in vascular aging
- From:
Chinese Journal of Geriatrics
2025;44(8):1031-1039
- CountryChina
- Language:Chinese
-
Abstract:
Vascular aging refers to the progressive decline in functional and structural integrity of blood vessels under physiological and pathological conditions, serving as the pathophysiological basis for systemic organ aging and age-related vascular diseases.With the acceleration of global population aging, vascular aging has emerged as a critical determinant of cardiovascular health.Its mechanisms involve cascade interactions among endothelial dysfunction, phenotypic switching of vascular smooth muscle cells, and extracellular matrix remodeling, with chronic inflammation and oxidative stress playing pivotal roles.Clinically, noninvasive quantification of vascular function and structure has been achieved through pulse wave velocity, flow-mediated dilation, and imaging modalities(ultrasound, CT/MRI), yet challenges persist regarding insufficient specificity of biomarkers and standardization of multimodal assessments.Among intervention strategies, conventional pharmacological agents(e.g., ACE inhibitors, statins) and lifestyle modifications(caloric restriction, exercise) delay vascular aging via multi-target regulatory mechanisms, while emerging therapies such as senolytics and stem cell-based therapies demonstrate promising therapeutic potential.Future research should prioritize the integration of interdisciplinary approaches to advance the clinical translation of the Chinese expert consensus on clinical assessment and intervention of vascular aging(2024 edition).
