The research progress and application potential of exosomes in the treatment of sarcopenia
10.3760/cma.j.issn.0254-9026.2025.04.023
- VernacularTitle:外泌体在肌少症治疗中的研究进展与应用潜力
- Author:
Mengran QIN
1
;
Yan WANG
1
;
Benchao DONG
1
;
Peichuan YANG
1
;
Jianxiong MA
1
Author Information
1. 天津大学天津医院(天津市天津医院) 骨科研究所，天津 300211
- Publication Type:Journal Article
- Keywords:
Exosomes;
Sarcopenia;
Skeletal muscle satellite cells;
Biomarkers
- From:
Chinese Journal of Geriatrics
2025;44(4):549-554
- CountryChina
- Language:Chinese
-
Abstract:
Sarcopenia, characterized by the loss of muscle mass and function, significantly impacts the quality of life in older adults and has emerged as a major global public health challenge.With the aging population, the incidence of sarcopenia continues to rise, necessitating urgent in-depth studies on effective treatments and its pathogenesis.Exosomes serve as effective carriers for intercellular substance transfer, participating in the physiological regulation and pathological changes of organic cells by transporting specific nucleic acids, proteins, and lipids.Although the potential role of exosomes in sarcopenia has been identified, the specific mechanisms remain poorly understood, and clinical applications are still in the early stages of exploration.This review outlines the role of exosomes from various sources in the communication of skeletal muscle satellite cells and their impact on the occurrence and development of sarcopenia.It also explores their potential applications as biomarkers and therapeutic strategies, providing new ideas and directions for the prevention and treatment of sarcopenia.As research progresses, exosomes are expected to lead to novel treatment options for patients with sarcopenia, ultimately improving their quality of life and health.
