Association between serum T3 levels and poor prognosis in patients with severe pulmonary tuberculosis
10.3760/cma.j.issn.0254-9026.2025.05.005
- VernacularTitle:血清三碘甲状腺原氨酸水平与重症肺结核患者不良预后相关性
- Author:
Xuan LEI
1
;
Yu XUE
1
;
Ming LEI
1
;
Yulin HUANG
1
;
Li WEN
1
Author Information
1. 首都医科大学附属北京胸科医院 北京市结核病胸部肿瘤研究所急诊科，北京 101149
- Publication Type:Journal Article
- Keywords:
Thyroid hormone T3;
Pulmonary tuberculosis;
Severity;
Prognosis;
Older adults
- From:
Chinese Journal of Geriatrics
2025;44(5):597-602
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the correlation between thyroid hormone levels and the 90-day prognosis in patients with severe pulmonary tuberculosis, with a particular focus on the impact of age.Methods:This retrospective cohort study included 156 patients(43 females, 113 males; ages ranging from 21 to 93 years)diagnosed with severe pulmonary tuberculosis between January 2022 and December 2023.Patients were categorized into deceased( n=46)and survived( n=110)groups based on their 90-day survival status.Further subcategorization into elderly and non-elderly subgroups was conducted.Thyroid hormone levels and other relevant laboratory markers were measured and analyzed. Results:Total triiodothyronine(TT3) [(0.92±0.36)nmol/L] and free triiodothyronine(FT3) [(2.19±0.87)pmol/L] in deceased group were lower than in survival group [TT3(1.09±0.38)nmol/L], FT3 [(2.79±0.99)pmol/L], both P<0.05.T3 levels positively correlated with 90-day survival (TT3: r=-0.202, P=0.011; FT3: r=-0.276, P<0.001).In elderly patients, this correlation was weakened (TT3: r=-0.071, P=0.526; FT3: r=-0.206, P=0.059), but remained significant in non-elderly patients (TT3: r=-0.360, P=0.002; FT3: r=-0.345, P=0.003).FT3 was a better prognostic indicator than TT3. Conclusions:Low serum T3 levels are indicative of a poor prognosis in severe pulmonary tuberculosis; however, their predictive value diminishes in elderly patients.
