Advances in animal models for studying human papillomavirus
10.3760/cma.j.cn112309-20240418-00135
- VernacularTitle:人乳头瘤病毒动物模型研究进展
- Author:
Qingfeng ZHANG
1
;
Qinghua HU
;
Weijin HUANG
Author Information
1. 中国药科大学药学院，南京 211198
- Publication Type:Journal Article
- Keywords:
Human papillomavirus;
Animal models;
Infection;
Vaccines
- From:
Chinese Journal of Microbiology and Immunology
2025;45(5):414-419
- CountryChina
- Language:Chinese
-
Abstract:
Human papillomavirus (HPV) can cause various tumors such as cervical cancer in women. Further study of HPV infection and its pathogenic mechanism, as well as the development of vaccines and anti-tumor drugs, have been hindered due to the strong host specificity and tissue affinity of HPV, along with the challenges in in vitro culture and the lack of animal infection models. To advance the study of HPV infection and its pathogenic mechanism and to development better prevention and treatment measures, it is important to establish an animal model that closely resembles the infection and pathogenesis pathways in humans. This article reviews previous research on HPV-related animal models using mice, rabbits, macaques, and Drosophila, including infectious models, tumor models, and transgenic models, aiming to provide reference for the selection of appropriate animal models for HPV-related research.
