Research progress in outer membrane vesicle of Klebsiella pneumoniae

VernacularTitle:肺炎克雷伯菌外膜囊泡研究进展
Author: Xinyu ZHU ¹ ; Jie YAN ; Mengyuan CHEN ; Qiang WANG
Author Information

1. 浙江中医药大学第二临床医学院，杭州　310053
Publication Type:Journal Article
Keywords: Klebsiella pneumoniae; Outer membrane vesicle; Bacterial infection; Pathogenicity
From: Chinese Journal of Microbiology and Immunology 2025;45(4):350-354
CountryChina
Language:Chinese
Abstract: Outer membrane vesicle (OMV) secreted by Klebsiella pneumoniae are nanoscale spherical proteoliposomes (20-400 nm) primarily composed of outer membrane components. OMV, initially considered byproducts of bacterial cell lysis, are now recognized as part of a unique bacterial secretion pathway known as the type 0 secretion system. OMV can deliver their cargo proteins, lipids, DNA, and toxins to target cells in a centralized, protected, and targeted manner, eliminating the need for direct contact between bacterial cells and target cells. In summary, OMV play a role in various biological processes, including intercellular communication, nutrient acquisition, horizontal gene transfer, bacterial competition, and virulence. This review focuses on the composition of Klebsiella pneumoniae OMV, their potential roles in bacterial survival and pathogenesis, and their promising applications as vaccine candidates for the prevention and treatment of Klebsiella pneumoniae infections.