Progress in the application of immune cell-derived extracellular vesicles in non-alcoholic fatty liver disease

VernacularTitle:免疫细胞来源细胞外囊泡在非酒精性脂肪性肝病应用中的研究进展
Author: Lamei DENG ¹ ; Hongli SONG
Author Information

1. 天津医科大学一中心临床学院，天津　300192
Publication Type:Journal Article
Keywords: Non-alcoholic fatty liver disease; Extracellular vesicles; Immune cells
From: Chinese Journal of Microbiology and Immunology 2025;45(5):441-447
CountryChina
Language:Chinese
Abstract: Non-alcoholic fatty liver disease (NAFLD) is one of the common chronic liver diseases with increasing incidence and prevalence. Given the current lack of effective therapeutic drugs, NAFLD has emerged as a focal point in hepatology research. The pathogenesis of NAFLD is complex, and immune cells play an important role in this process. Immune cells can release extracellular vesicles (EVs), which carry bioactive cargo such as proteins and microRNAs, thereby influencing the progression of NAFLD. Moreover, EVs are characterized by the advantages of good biocompatibility and low immunogenicity, making them widely explored as drug carriers. Exploring the application of immune cell-derived EVs in NAFLD may provide new directions for the treatment of NAFLD.