T cell-based novel therapeutic approaches for autoimmune diseases
10.3760/cma.j.cn112309-20240611-00210
- VernacularTitle:基于T细胞的自身免疫性疾病的新型治疗策略
- Author:
Xin ZHOU
1
;
Yuezhong DING
1
;
Jiangnan XU
1
Author Information
1. 首都医科大学基础医学院免疫学系，北京 100069
- Publication Type:Journal Article
- Keywords:
Immunotherapy;
Autoimmune diseases;
CAR-T cells;
CAR-Treg cells;
Co-inhibitory molecules
- From:
Chinese Journal of Microbiology and Immunology
2025;45(5):433-440
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, the incidence of autoimmune diseases is increasing, exerting a profound impact on the quality of people′s life. However, current research on the pathogenesis and therapeutic approaches for these diseases remains limited. T cells play a central role in the initiation and progression of autoimmune diseases. As a crucial component of the body′s immune system, T cells are essential in mediating immune tolerance and maintaining immune homeostasis. Recent insights into the delicate mechanisms and therapeutic potential of the regulation of T cells provide an opportunity to develop advanced strategies for the treatment of autoimmune diseases, which would significantly mitigate the adverse effects associated with conventional immunosuppression and antibody therapies. This article reviews the recent progress in the development of novel therapeutic strategies based on T cells for autoimmune diseases, aiming to provide ideas for further research.
