Research progress in the immunomodulatory mechanisms mediated by galectin-9

VernacularTitle:半乳糖凝集素-9介导的免疫调节机制研究进展
Author: Yiwen XU ¹ ; Jun LING ; Bing ZHU ; Limei YU ; Shaoli YOU
Author Information

1. 遵义医科大学附属医院贵州省细胞工程重点实验室，遵义　563003
Publication Type:Journal Article
Keywords: Galectin-9; Tim-3; CD44; 4-1BB; Dectin-1
From: Chinese Journal of Microbiology and Immunology 2025;45(4):355-360
CountryChina
Language:Chinese
Abstract: Galectin-9 (Gal-9), a member of the β-galactoside-binding lectin family, is widely expressed in various tissues and cells. It can specifically bind to multiple glycoprotein receptors, including the receptors of Tim-3, CD44, 4-1BB/CD137, and Dectin-1, thereby regulating the activity of immune cells and participating in crucial physiological and pathological processes such as immune regulation and tumor development. Given its role in immunomodulation, Gal-9 is considered a potential target for immunotherapy, showing promising prospects in the treatment of various diseases, including autoimmune disorders, transplantation rejection, pregnancy complications, inflammation, infection, and cancer. This review summarizes the biological effects mediated by Gal-9 upon binding to its receptors, which may help to explore the potential application value of Gal-9 in clinical diagnosis and therapy.